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Oral administration has the benefit of high patient compliance and has demonstrated the potential to target brain iron pathology, especially with BBB-permeant agents like DFP

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Compounds such as EGCG and apigenin promote apoptosis in melanoma cells by modulating pathways like MAPK and PI3K-AKT, while green tea polyphenols inhibit histone deacetylase (HDAC) and activate histone acetyltransferase (HAT), reactivating tumor-suppressor genes silenced during melanoma progression 138,148